TARGETED STUDIES
Colon Cancer
Biomedicine & Preventive Nutrition 2012
Jedinak A, et al.
Phytomedicine 2011
This study shows that a protein called P53, which is involved in DNA surveillance, could be one target of Ganoderic acid, and this could inhibit growth of human colon cancer cells.
Nian-Hong Chen, et al.
Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK)
Nutrition & Cancer 2010
The authors show that triterpene extract from Ganoderma, inhibits human colon cancer cell growth by blocking cell division. They identify a specific signaling protein in the cancer cells (p38MAPK) that causes this arrest and conclude suggesting the use of Ganoderma as a natural product for the treatment of colon cancer.
Thyagarajan A, et al.
A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas
Clinical study showing that Ganoderma water extract reduced size and number of colorectal adenomas over 12 months.
Ganoderic acid Me induces G1 arrest in wild-type p53 human tumor cells while G1/S transition arrest in p53-null cells,.
Okas, et al.
Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer
International Immunopharmacology 2006
Clinical study with advanced colorectal cancer patients over a 12 week period given 5.4g of Ganderma per day. 41 out of the 47 patients showed increases in immune cells (lymphocytes), suggesting Ganoderma may have potential immuno-modulating effect in patients with advanced colorectal cancer.
Chen X, et al.
Ganoderma tsugae extracts inhibit colorectal cancer cell growth via G(2)/M cell cycle arrest
Journal of Ethnopharmacology 2008
This study shows that Ganoderma extracts block cell division in human colorectal cancer cells. Also that the extract caused tumor shrinkage in cancerous mice.
Shis-Chung Hsu et al.
