DISEASE BIOLOGY STUDIES
Journal of Agricultural Food Chemistry, 2012
Fragments of Ganoderma polysaccharides are able to induce immune responses in human immune cell. A fragment containing glucuronic acid and glucose residues is most potent in this immune cell assay.
Tsai CC et al.
Antitumor Properties of Ganoderma lucidum Polysaccharidis and Terpenoids
Annual Review of Biomedical Sciences 2012
Reviews the direct effect of the polysaccharides and terpeoids of Ganoderma have on tumor cells including apoptosis (cell death) and interference in the cell cycle. Their data indicates that Ganoderma can be used as a complementary tool for treatment of cancer patients.
Marcela Camargo et al
Basic and Clinical Pharmacology and Toxicology, 2011
The immune system in patients with cancer often fails to control tumor growth because of deficient immunogenicity of tumor cells Ganoderma polysaccharides are shown to activate lymphocyte proliferation in cancer cells (melanoma).
Sun LX, et al.
Ganoderma lucidum total triterpenes prevent radiation-induced DNA damage and apoptosis in splenic lymphocytes in vitro.
Mutation Research, 2011
Study showing that Ganoderma triterpenes have a remarkable ability to protect normal cells from radiation-induced damage. Radiation can cause cancer, so relevant to cancer prevention.
Simina TP, et al.
Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum (2011)
Acta Pharmacologica Sinica, 2011
Ganoderma polysaccharides inhibit growth of solid tumors.
Ganoderma lucidum,the most eclectic mushroom: useful in oncology or against virus, inflammation or metabolic diseases.
Joseph S, et al.
Apoptic and Immune Restoration Effects of Ganoderic Acids Define a New Prospective for Complementary Treatment of Cancer (Radwan et al) - J. Clinical Cell Immunology, 2011
Journal of Clinical and Cellular Immunology, 2011
Readable review of the stimulatory effects of Ganoderma ganoderic acids on apoptosis and the immune system.
Faisal F.Y. Radwan et al.
Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells
Phytomedicine 2010
Five different ganoderic acids inhibit proliferation of human HeLa cancer cells Ganoderic acids might exert their cytotoxicity by altering proteins involved in cell proliferation and/or cell death, carcinogenosis, oxidative stress, calcium signaling and ER stress.
Q.-X. Yue et al.
GLIS, a bioactive proteoglycan fraction from Ganoderma lucidum, displays anti- tumour activity by increasing both humoral and cellular immune response
Life Sciences 2010
First report that a Ganoderma proteoglycan (a protein with attached carbohydrate) called GLIS can have anti-cancer effects. GLDIS given to mice with sarcomas inhibited growth of the sarcoma by 60%.
Jingsong Zhang et al.
The in vitro and in vivo experimental evidences disclose the chemopreventive effects of Ganoderma lucidum on cancer invasion and metastasis.
Clinical and Experiemental Metastasis, 2010
Review of how Ganoderma modifies activation of intracellular signaling proteins, resulting in suppression of genes thought to be involved in metastasis.
Weng CJ, et al.
Antitumor activity of extracts of Ganoderma lucidum and their protective effects on damaged HL-7702 cells induced by radiotherapy and chemotherapy
Journal of Chinese Materia Medica 2006
Ganoderma is useful to support the immune system with people undergoing chemotherapy and radiotherapy. Ganoderma had protective effects on damaged normal cells induced by radiotherapy and chemotherapy.
Wang DJ, et al.
Polysaccharide Purified from Ganoderma lucidum Induces Gene Expression Changes in Human Dendritic Cells and Promotes T Helper 1 Immune Response in BALB/c Mice
Molecular Pharmacology 2006
This study shows that one of the active molecules in Ganoderma is a branched glucan polysaccharide. The polysaccharide can stimulate the immune system, in part by inducing the expression of interleukin molecules in the bloodstream. No analysis of cancer effects, but indirectly relevant to cancer.
Yu-Li Lin et al.
