TARGETED STUDIES
Stomach / Gastric Cancer
Journal of Ethnopharmacology, 2010
Building on studies elsewhere, the authors investigate how Ganoderma extract leads to leukemia cell apoptosis. These show that the extract causes reduction in the levels of anti-apoptosis proteins in the leukemia cells thereby causing them to die.
Diez JC et al, Universidad de Alcala, Spain
Eva Calvino, et al.
Evidence Based Complementary and Alternative Medicine 2009
Results show that Ganoderma polysaccharide F3 can cause human leukemia cells to differentiate into macrophages, thus ending uncontrolled cell division. The same group has also shown that F3 can lead to apoptosis.
Chan WK, et al.
Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells
Leukemia Research, 2006
Using 26 human cancer cell lines, the authors show that Ganoderma extracts cause many of them to stop dividing. Leukemia, lymphoma and myeloma cell lines were most sensitive to the Ganoderma extracts. The extract blocked the cell division at the G21M stage.
Claudia I. Muller, et al.
Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction
BMC Genomics, 2007
Results show that a polysaccharide extracted from Ganoderma spores, called F3 is responsible for anti-tumor activity. F3 binds to the surface of human leukemia cells and triggers apoptosis (cell death) in them.
Chan WK, et al.
Ganoderma lucidum Polysaccharides Induce Macrophage-like Differentiation in Human Leukemia
Evidence Based Complementary and Alternative Medicine 2009
Results show that Ganoderma polysaccharide F3 can cause human leukemia cells to differentiate into macrophages, thus ending uncontrolled cell division. The same group has also shown that F3 can lead to apoptosis. They suggest that the Ganoderma polysaccharide F3 can bring cancer to an end whether by cell differentiation or cell death.
Jia-Wei Hsu, et al.
