TARGETED STUDIES
Lung Cancer
Carcinogenesis, 2011
The authors show that a protein termed LZ-8 in Ganoderma, rather than a polysaccharide or a triterpene, blocks growth of human lung cancer cells. They suggest that the LZ-8 stimulates the activity of a protein in the cancer cells that surveys the DNA and pushes cancer cells into apoptosis.
Wu CT, et al.
Cancer Letters, 2009
Multi drug resistance is a major problem in small cell lung cancer. The results from this study shows that Ganoderma is cytotoxic to both drug-sensitive and drug-resistance small cell lung cancer cells treated with chemotherapeutic drugs, and can reverse resistance to chemotherapeutic drugs.
David Sadava, et al.
Enhancement of IL-2 and IFN-gamma expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo
International Immunopharacology 2007
Shows that ganoderic acid, a lanostane triterpenoid in Ganoderma is among the inhibitory molecules in a human lung cancer cell assay.
Wang G, et al.
Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells
Life Sciences, 2006
The findings show that Ganoderma markedly induced apoptosis of metastatic lung tumor cells. It did this through intrinsic pathway related to mitochondral dysfunction and p53 expression (p53 , is a tumor suppressor protein that in humans is involved in preventing cancer)
Wen Tang et al.
A Randomized, Placebo-Controlled, Multicenter Study of Ganoderma lucidum(W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) Polysaccharides in Patients with Advanced Lung Cancer
International Journal of Medicinal Mushrooms 2003
68 patients with advanced lung cancer were given Ganoderma. Compared to the control group, after 12 weeks these patients showed a significant increase in lymphocyte mitogenic reactivity (increase in natural killer cells).
Yihuai Guo, et al.
