TARGETED STUDIES
Prostate Cancer
The Open Prostate Cancer Journal 2010
This is a review of the effect of ganoderic acid (from Ganoderma) on human prostate cancer cells. The summary is that GA is toxic to the cancer cells, whether they need male hormones to grow or not. The GA also reduced the spread of the prostate cancer cells to the bone.
Benjamin M. Johnson, et al.
The Open Bioactive Compounds Journal 2009
Ganoderic acid, a triterpene from Ganoderma spores, inhibits prostate cancer cells. The authors show that GA block the receptors on the cancer cells for male hormones, so that the cells cannot divide. Prostate cancer has a high incidence of bone metastasis. Ganoderic acid DM can block osteoclastogenesis.
Jie Liu, et al.
Androgen receptor-dependent and independent mechanisms mediate Ganoderma lucidum activities in LNCaP prostate cancer cells
International Journal of Oncology 2007
Ganoderma spore extracts trigger apoptosis in human prostate cancer cells. The extracts activate caspases in the cancer cells. These are proteases that bring about cell disassembly in cancer cells (apoptosis).
Ben-Zion Zaidman, et al.
Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-B1 from prostate cancer cells
Biochemical & Biophysical Research Communication, 2005
The authors show that Ganoderma extracts block the development of blood vessels needed to supply prostate cancer cells with oxygen and nutrients, causing the prostate cancer to die. They also reveal that the extracts do this by inhibiting a key signaling molecule in the prostate cancer cells themselves.
Gwenaelle Stanley, et al.
